Covid vaccine

[iriejohn]

Information below about increasing the interval between Astrazeneca doses from 6 to 12 weeks which significantly improves immune response.

https://www.thelancet.com/journals/lanc ... 3/fulltext

Background

The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4–12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered.

Findings

Between April 23 and Dec 6, 2020, 24 422 participants were recruited and vaccinated across the four studies, of whom 17 178 were included in the primary analysis (8597 receiving ChAdOx1 nCoV-19 and 8581 receiving control vaccine). The data cutoff for these analyses was Dec 7, 2020. 332 NAAT-positive infections met the primary endpoint of symptomatic infection more than 14 days after the second dose. Overall vaccine efficacy more than 14 days after the second dose was 66·7% (95% CI 57·4–74·0), with 84 (1·0%) cases in the 8597 participants in the ChAdOx1 nCoV-19 group and 248 (2·9%) in the 8581 participants in the control group. There were no hospital admissions for COVID-19 in the ChAdOx1 nCoV-19 group after the initial 21-day exclusion period, and 15 in the control group. 108 (0·9%) of 12 282 participants in the ChAdOx1 nCoV-19 group and 127 (1·1%) of 11 962 participants in the control group had serious adverse events. There were seven deaths considered unrelated to vaccination (two in the ChAdOx1 nCov-19 group and five in the control group), including one COVID-19-related death in one participant in the control group. Exploratory analyses showed that vaccine efficacy after a single standard dose of vaccine from day 22 to day 90 after vaccination was 76·0% (59·3–85·9). Our modelling analysis indicated that protection did not wane during this initial 3-month period. Similarly, antibody levels were maintained during this period with minimal waning by day 90 (geometric mean ratio [GMR] 0·66 [95% CI 0·59–0·74]). In the participants who received two standard doses, after the second dose, efficacy was higher in those with a longer prime-boost interval (vaccine efficacy 81·3% [95% CI 60·3–91·2] at ≥12 weeks) than in those with a short interval (vaccine efficacy 55·1% [33·0–69·9] at <6 weeks). These observations are supported by immunogenicity data that showed binding antibody responses more than two-fold higher after an interval of 12 or more weeks compared with an interval of less than 6 weeks in those who were aged 18–55 years (GMR 2·32 [2·01–2·68]).

My highlights

[we]

Beware, they changed the definition of efficacy for the Covid vaccine. Historically, efficacy means preventing infection. For Covid vaccines efficacy means preventing symptoms. These vaccine could have 100% or 0% efficacy at preventing infections.

"Both Pfizer and Moderna report that their vaccines show approximately 95% efficacy at preventing both mild and severe symptoms of COVID-19."

[iriejohn]

The way the term "efficacy" is used is perfectly clear in the Lancet paper. I suggest you read the .pdf file.

(A person can not produce antibodies without becoming infected).

[Dave_5280]

In a little over a month, Covid vaccine doses administered worldwide total just over 200 million, 60 in the U.S. and 40 in China, and the rest in other countries. So about 5.5 million doses administered per day.

[we]

The way the term "efficacy" is used is perfectly clear in the Lancet paper. I suggest you read the .pdf file.

(A person can not produce antibodies without becoming infected).

Yes, that article proves my point. Efficacy for the Covid vaccine does not mean the same thing as efficacy for the measles vaccine. I would suggest that you read it also.

[Matteo V]

The way the term "efficacy" is used is perfectly clear in the Lancet paper. I suggest you read the .pdf file.

(A person can not produce antibodies without becoming infected).

Infection (active viral replication) is not necessary to produce antibodies in the case of true "inactivated virus" vaccines.

And the new mRNA treatments also do not utilize an infection, or even an inactivated virus. They insert genetic material into your cells force those cells to produce a product which your immune system then responds to.




2018 - prior to changing the definition of vaccines to include mRNA gene therapy treatments such as the Pfizer and Moderna treatments.

https://www.google.com/url?sa=t&source= ... RXvr8MV6jv



Post 2020 after changing the definition of vaccines to include mRNA gene therapy treatments such as the Pfizer and Moderna treatments.

https://www.google.com/url?sa=t&source= ... GDsHXwIeRQ

[iriejohn]

The way the term "efficacy" is used is perfectly clear in the Lancet paper. I suggest you read the .pdf file.

(A person can not produce antibodies without becoming infected).

Edit for the mouthbreathers:

(A person can not produce antibodies without becoming infected or tricked into believing that it is infected).

[Matteo V]

The way the term "efficacy" is used is perfectly clear in the Lancet paper. I suggest you read the .pdf file.

(A person can not produce antibodies without becoming infected).

Edit for the mouthbreathers:

(A person can not produce antibodies without becoming infected or tricked into believing that it is infected).

Thank you.

Us mouth breathers appreciate the accuracy.

[Matty V]

Do they inject a micro chip/tracking device at the same time as altering your genetic make up? (Asking for a friend..)

[Havre]

Related to breathing with your mouth. Why is that still allowed? Wouldn't it be better if we all used our noses for breathing? And don't get me started on talking.

Insane you say? I would agree, but is it so hard for you not to talk on public transport? Or breathing through your nose when in the supermarket? The logic seems to work for masks so...

Anyway. Some good news from the EU it seems (end of last month):

7.3 with respect to ensuring high vaccine uptake:
7.3.1 ensure that citizens are informed that the vaccination is NOT mandatory and that no one is politically, socially, or otherwise pressured to get themselves vaccinated, if they do not wish to do so themselves;
7.3.2 ensure that no one is discriminated against for not having been vaccinated, due to possible health risks or not wanting to be vaccinated;

Sensible. We'll see if they live up to it. In Israel you are now getting free pizza if you take the vaccine so